Min-Yi Lee, M.D. 1, Chih-Sheng Chu, M.D. 2, Kun-Tai Lee, M.D. 2, Chan-Ming Wu, M.D. 1, Ho-Min Su, M.D. 2, Shin-Jing Lin, M.D. 2, Sheng-Hsuing Sheu, M.D. 2, Wen-Ter Lai, M.D. 2 *
1)Division of Cardiology, Department of Internal Medicine, Kaohsiung Municipal United Hospital, Kaohsiung, Taiwan
2)Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Background: Pulse wave velocity (PWV), a relevant indicator of arterial stiffness, can be measured noninvasively with a variety of automatic devices, but most are complexly equipped. We developed a novel index for estimating arterial stiffness as QPV interval, which was determined by means of surface electrocardiogram and Doppler ultrasound of the brachial artery simultaneously.
Hypothesis: This study aimed to validate the QPV interval as an exact and convenient index for estimation of arterial stiffness.
Methods: Forty-seven patients with untreated essential hypertension and 19 normotensive subjects were enrolled. Brachial-ankle PWV (baPWV) was measured using an automatic volume-plethysmographic apparatus, and Doppler ultrasound was implemented sequentially to measure the QPV interval in each subject. Clinical biochemistry and echocardiography were performed on the same day.
Results: Mean baPWV was significantly higher in hypertensive patients than in normotensive subjects (p = 0.002), whereas mean QPV interval was significantly shorter in hypertensive patients than in the normotensive group (p = 0.019). A simple regression analysis demonstrated an inverse correlation between the QPV interval and baPWV (r = -0.671, p < 0.001) in all enrolled subjects. In a stepwise regression model that adjusted for age, systolic blood pressure, and other determinants of baPWV, the negative association remained between the QPV interval and baPWV (p < 0.001).
Conclusion: The QPV interval correlates inversely with baPWV, independent of age and other determinants of baPWV; hence, the QPV interval can serve as a simple and convenient index for assessing arterial stiffness in clinical practice.
Hypothesis: This study aimed to validate the QPV interval as an exact and convenient index for estimation of arterial stiffness.
Methods: Forty-seven patients with untreated essential hypertension and 19 normotensive subjects were enrolled. Brachial-ankle PWV (baPWV) was measured using an automatic volume-plethysmographic apparatus, and Doppler ultrasound was implemented sequentially to measure the QPV interval in each subject. Clinical biochemistry and echocardiography were performed on the same day.
Results: Mean baPWV was significantly higher in hypertensive patients than in normotensive subjects (p = 0.002), whereas mean QPV interval was significantly shorter in hypertensive patients than in the normotensive group (p = 0.019). A simple regression analysis demonstrated an inverse correlation between the QPV interval and baPWV (r = -0.671, p < 0.001) in all enrolled subjects. In a stepwise regression model that adjusted for age, systolic blood pressure, and other determinants of baPWV, the negative association remained between the QPV interval and baPWV (p < 0.001).
Conclusion: The QPV interval correlates inversely with baPWV, independent of age and other determinants of baPWV; hence, the QPV interval can serve as a simple and convenient index for assessing arterial stiffness in clinical practice.
Keywords: arterial stiffness • pulse wave velocity • QPV interval • Doppler ultrasound
Volume 29, Issue 8 , Pages 345 - 351
© 2006 Verlag Chemie, GmbH
© 2006 Verlag Chemie, GmbH
No comments:
Post a Comment