HYPERINSULINEMIA AND LEFT VENTRICULAR HYPERTROPHY IN PATIENTS WITH LONG TERM HYPERTENSIONO.Yarynkina, O.Kupchinska, L.Zelenenka, M.Mospan, N.Tchyrulneva
Department of Hypertension, Institute of Cardiology, Kiev, Ukraine
Objective: The hyperinsulinemia has been associated with higher risk of target organ-damage. We evaluate relationship between the left ventricular function characteristics and insulinemia in the essential hypertension (EH) under 10 years observation.
Department of Hypertension, Institute of Cardiology, Kiev, Ukraine
Objective: The hyperinsulinemia has been associated with higher risk of target organ-damage. We evaluate relationship between the left ventricular function characteristics and insulinemia in the essential hypertension (EH) under 10 years observation.
Design and methods: We examined 57 patients with moderate EH at the primary appeal to the hospital and in 10 years after. Immunoreactive insulin (IRI) concentration was measured under standard oral glucose tolerance test (OGTT) at fasting and 60 and 120 min by radioimmunoassay. Left ventricular values were measured by echocardiography. Blood samples were drawn for the determination plasma creatinine and lipid concentration.
Results: Systolic blood pressure did not changed (162+7,2 and 165+5,3 mmHg accordingly) but DBP was significantly lower (103+3,3 and 97+4,5 mmHg, p<0,001)>
We found correlation of high IRI level under OGTT with LVMI2 (r=0,39,p<0,05) r="0,34,p<0,05).">Conclusions: There are hyperinsulinemia in more than 50 % patients with longitudinal arterial hypertension that associated with LVMI increasing. This information indicates that hyperinsulinemia plays significant role in LV hypertrophy.
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